Sigma Receptors

Author: Rae R. Matsumoto
Publisher: Springer Science & Business Media
ISBN: 0387365141
File Size: 15,42 MB
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This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.

The Opiate Receptors

Author: Gavril W. Pasternak
Publisher: Springer Science & Business Media
ISBN: 9781607619932
File Size: 52,60 MB
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This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.

Sigma Receptors Their Role In Disease And As Therapeutic Targets

Author: Sylvia B. Smith
Publisher: Springer
ISBN: 3319501747
File Size: 54,89 MB
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Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

Sigma Receptors

Author: Yossef Itzhak
Publisher:
ISBN:
File Size: 72,80 MB
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This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.

The Journal Of Nuclear Medicine

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Publisher:
ISBN:
File Size: 27,64 MB
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Biochemical Studies On The Sigma 1 Receptor

Author: Subramaniam Ramachandran
Publisher: ProQuest
ISBN:
File Size: 71,68 MB
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The data and findings presented in this thesis area contribute towards understanding the biology of the sigma-1 receptor. The pure sigma-1 receptor is a useful tool that for biochemical and structural experiments which were previously not possible. The work presented here also places sphingosine in the list of possible sigma-1 receptor endogenous ligands. Studies with the K+ channel have uncovered a broader role for sigma ligands in modulating channel regulation.

Receptor Chemistry Towards The Third Millennium

Author: M. Gianella
Publisher: Elsevier
ISBN: 9780080540405
File Size: 33,29 MB
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Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs. This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.

Cancer Research

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ISBN:
File Size: 35,81 MB
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Iron Metabolism

Author: Robert Crichton
Publisher: John Wiley & Sons
ISBN: 1118925637
File Size: 55,51 MB
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Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Introduction To Cellular Signal Transduction

Author: Ari Sitaramayya
Publisher: Springer Science & Business Media
ISBN: 1461219906
File Size: 34,23 MB
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Our understanding of biological communication has grown significantly during the past decade. The advances in knowledge about the chemical nature of signals and their corresponding reception by specialized cells have led to identification, characterization, purification, cloning, and expression of specific receptor molecules. While the earlier literature emphasized com partmentalized treatment of informational molecules and their interaction with receptors, the progress in the recent past has allowed cross-fertilization in the examination of the of actions and mechanisms of steroid and protein hormones and other messengers. Investigators now have an increased ap preciation of the multiple effects of specific hormones and of the diverse responses by receptor proteins to closely related ligands. The task of compil ing this enormous literature into a focused treatise was undertaken with the launching of the series Hormones in Health and Disease. This latest volume, An Introduction to Cellular Signal Transduction, complements the previous monographs in the series and brings to the fore recent developments in the field of biochemical communication. This volume combines discussions on the basic tenets of the signal transduction process and its relevance to health and disease. While various chapters provide exhaustive dissection of specific topics for researchers in the field, the book is also an excellent vehicle for introducing students and new investigators to the subject. The contributors of the chapters are active and accomplished scientists brought together on a common platform by the editor, Dr.